Satb1 and Satb2 regulate embryonic stem cell differentiation and Nanog expression.

@article{Savarese2009Satb1AS,
  title={Satb1 and Satb2 regulate embryonic stem cell differentiation and Nanog expression.},
  author={Fabio Savarese and Amparo D{\'a}vila and Robert Nechanitzky and Inti Alberto de la Rosa-Vel{\'a}zquez and Carlos Filipe Pereira and Rudolf Engelke and Keiko F Takahashi and Thomas Jenuwein and Terumi Kohwi-Shigematsu and Amanda G Fisher and Rudolf Grosschedl},
  journal={Genes & development},
  year={2009},
  volume={23 22},
  pages={2625-38}
}
Satb1 and the closely related Satb2 proteins regulate gene expression and higher-order chromatin structure of multigene clusters in vivo. In examining the role of Satb proteins in murine embryonic stem (ES) cells, we find that Satb1(-/-) cells display an impaired differentiation potential and augmented expression of the pluripotency determinants Nanog, Klf4, and Tbx3. Metastable states of self-renewal and differentiation competence have been attributed to heterogeneity of ES cells in the… CONTINUE READING
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