Sarpogrelate HCl, a selective 5-HT2A antagonist, retards the progression of atherosclerosis through a novel mechanism.

@article{Hayashi2003SarpogrelateHA,
  title={Sarpogrelate HCl, a selective 5-HT2A antagonist, retards the progression of atherosclerosis through a novel mechanism.},
  author={Toshio Hayashi and Daigo Sumi and Hisako Matsui-Hirai and Akiko Fukatsu and Juliet Arockia Rani P and Hatsuyo Kano and Taku Tsunekawa and Akihisa Iguchi},
  journal={Atherosclerosis},
  year={2003},
  volume={168 1},
  pages={
          23-31
        }
}
Although sarpogrelate HCl is widely used for the prevention of arterial thrombosis, its effect on atherosclerosis is unknown. Accordingly, we here investigated the effects of sarpogrelate HCl on a rabbit model of atherosclerosis. Male rabbits were fed a 0.5% cholesterol diet (HCD) (Gp 1), HCD with vitamin E (Gp 2), HCD with vitamin E and sarpogrelate (Gp 3), or HCD with sarpogrelate alone (Gp 4) for 8 weeks. The atherosclerotic area was decreased by feeding of vitamin E and sarpogrelate (16.9… Expand
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