Saredutant, an NK2 receptor antagonist, has both antidepressant-like effects and synergizes with desipramine in an animal model of depression

@article{Overstreet2010SaredutantAN,
  title={Saredutant, an NK2 receptor antagonist, has both antidepressant-like effects and synergizes with desipramine in an animal model of depression},
  author={David H. Overstreet and Vanessa Naimoli and G. E. Griebel},
  journal={Pharmacology Biochemistry and Behavior},
  year={2010},
  volume={96},
  pages={206-210}
}
Previous work established that saredutant, an NK2 receptor antagonist, has antidepressant and anxiolytic-antistress effects in a variety of rodent models. The purpose of the present investigation was two-fold: to confirm the antidepressant-like effects of saredutant using a genetic animal model of depression, the Flinders Sensitive Line (FSL) rat, and to assess whether saredutant might synergize with desipramine to produce antidepressant-like effects at doses not seen with the individual… CONTINUE READING
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