Sarcospan: a small protein with large potential for Duchenne muscular dystrophy

  title={Sarcospan: a small protein with large potential for Duchenne muscular dystrophy},
  author={Jamie L. Marshall and Rachelle H. Crosbie-Watson},
  booktitle={Skeletal Muscle},
Purification of the proteins associated with dystrophin, the gene product responsible for Duchenne muscular dystrophy, led to the discovery of the dystrophin-glycoprotein complex. Sarcospan, a 25-kDa transmembrane protein, was the last component to be identified and its function in skeletal muscle has been elusive. This review will focus on progress over the last decade revealing that sarcospan is an important regulator of muscle cell adhesion, strength, and regeneration. Investigations using… CONTINUE READING
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