Sarcoplasmic reticulum proteins in heart failure.

  title={Sarcoplasmic reticulum proteins in heart failure.},
  author={Stephan E. Lehnart and Wolfgang Schillinger and Burkert Pieske and Juergen Prestle and Hanjorg Just and Gerd Hasenfuss},
  journal={Annals of the New York Academy of Sciences},
Altered calcium homeostasis may play a key role in the pathophysiology of human heart failure. Levels of sarcoplasmic reticulum (SR) proteins and sarcolemmal Na(+)-Ca2+ exchanger were analyzed by Western blot in failing and nonfailing human myocardium and related to myocardial function. Levels of the SR calcium release channel and of calcium storage proteins (calsequestrin and calreticulin) were not different in nonfailing and failing hearts. However, proteins involved in calcium removal were… CONTINUE READING

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