Sarcoplasmic reticulum-mitochondrial through-space coupling in skeletal muscle.

  title={Sarcoplasmic reticulum-mitochondrial through-space coupling in skeletal muscle.},
  author={Robert T. Dirksen},
  journal={Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme},
  volume={34 3},
The skeletal muscle contractile machine is fueled by both calcium and ATP. Calcium ions activate the contractile machinery by binding to troponin C and relieving troponin-tropomyosin inhibition of actinomyosin interaction. ATP binding to myosin during the contractile cycle results in myosin detachment from actin, and energy liberated from subsequent ATP hydrolysis is then used to drive the next contractile cycle. ATP is also used to lower myoplasmic calcium levels during muscle relaxation. Thus… CONTINUE READING
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