Sarcoplasmic reticulum in aged skeletal muscle.

  title={Sarcoplasmic reticulum in aged skeletal muscle.},
  author={Alfredo Margreth and Ernesto Damiani and Elena Bortoloso},
  journal={Acta physiologica Scandinavica},
  volume={167 4},
A decrease in muscle mass and strength and a slowing of muscle contraction are common features of the ageing process. Recent advances in basic biochemical knowledge have provided new insights into pathogenetic mechanisms underlying age-related changes in the excitation-contraction coupling process, Ca2+-transients and isometric twitch-contraction time. Sarcoplasmic reticulum (SR) Ca2+-pumps are not basically altered in physiological ageing, but several aspects of the Ca2+-transport system… CONTINUE READING
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