Sarcoplasmic reticulum Ca2+ release is not a dominating factor in sinoatrial node pacemaker activity.

@article{Honjo2003SarcoplasmicRC,
  title={Sarcoplasmic reticulum Ca2+ release is not a dominating factor in sinoatrial node pacemaker activity.},
  author={Haruo Honjo and Shin Inada and Matthew K Lancaster and Mitsuru Yamamoto and R. Niwa and Sandra A. Jones and Nitaro Shibata and Kazuyuki Mitsui and Toshiyuki Horiuchi and Kaichiro Kamiya and Itsuo Kodama and Mark R. Boyett},
  journal={Circulation research},
  year={2003},
  volume={92 3},
  pages={
          e41-4
        }
}
Recent work on isolated sinoatrial node cells from rabbit has suggested that sarcoplasmic reticulum Ca2+ release plays a dominant role in the pacemaker potential, and ryanodine at a high concentration (30 micromol/L blocks sarcoplasmic reticulum Ca2+ release) abolishes pacemaking and at a lower concentration abolishes the chronotropic effect of beta-adrenergic stimulation. The aim of the present study was to test this hypothesis in the intact sinoatrial node of the rabbit. Spontaneous activity… CONTINUE READING

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