Sarcoplasmic reticulum Ca2+ refilling controls recovery from Ca2+-induced Ca2+ release refractoriness in heart muscle.

@article{Szentesi2004SarcoplasmicRC,
  title={Sarcoplasmic reticulum Ca2+ refilling controls recovery from Ca2+-induced Ca2+ release refractoriness in heart muscle.},
  author={P{\'e}ter Szentesi and Christophe Pignier and Marcel Egger and Evangelia G Kranias and E. Niggli},
  journal={Circulation research},
  year={2004},
  volume={95 8},
  pages={807-13}
}
In cardiac muscle Ca2+-induced Ca2+ release (CICR) from the sarcoplasmic reticulum (SR) is initiated by Ca2+ influx via L-type Ca2+ channels. At present, the mechanisms underlying termination of SR Ca2+ release, which are required to ensure stable excitation-contraction coupling cycles, are not precisely known. However, the same mechanism leading to refractoriness of SR Ca2+ release could also be responsible for the termination of CICR. To examine the refractoriness of SR Ca2+ release, we… CONTINUE READING
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Ca2 controls recovery from refractoriness and termination of CICR in cardiac muscle

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SR Ca 2  controls recovery from refractoriness and termination of CICR in cardiac muscle

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SR Ca determines recovery of CICR from refractoriness in cardiac myocytes

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