Sarcoplasmic/endoplasmic reticulum Ca2+ ATPase C674 promotes ischemia- and hypoxia-induced angiogenesis via coordinated endothelial cell and macrophage function.

@article{Mei2014SarcoplasmicendoplasmicRC,
  title={Sarcoplasmic/endoplasmic reticulum Ca2+ ATPase C674 promotes ischemia- and hypoxia-induced angiogenesis via coordinated endothelial cell and macrophage function.},
  author={Yu Mei and Melissa D Thompson and Yasunaga Shiraishi and Richard Alan Cohen and Xiaoyong Tong},
  journal={Journal of molecular and cellular cardiology},
  year={2014},
  volume={76},
  pages={275-82}
}
Ischemia is a complex phenomenon modulated by the concerted action of several cell types. We have identified that sarcoplasmic/endoplasmic reticulum Ca(2+) ATPase 2 (SERCA 2) cysteine 674 (C674) S-glutathiolation is essential for ischemic angiogenesis, vascular endothelial growth factor (VEGF)-mediated endothelial cell (EC) migration and network formation… CONTINUE READING