author={Avan Aihie Sayer},
  journal={BMJ : British Medical Journal},
  • A. Sayer
  • Published 10 August 2010
  • Medicine
  • BMJ : British Medical Journal
A research agenda has been set, but recognition in clinical practice is lagging behind 


Associations between low muscle mass, blood-borne nutritional status and mental health in older patients

Low muscle mass is associated with poor blood-borne poor nutritional status and mental health in hospitalized older patients, however, this is partly explained by underlying co morbidity.

Association between Sarcopenia and Immediate Complications and Mortality in Patients with Oral Cavity Squamous Cell Carcinoma Undergoing Surgery

Sarcopenia should be assessed before surgery to identify high-risk patients who require a more intensive approach to minimize complications and may be clinically helpful in tailoring treatment strategies for patients with OSCC.

Handgrip strength is associated with risk of falls in physically active older women.

Results indicated that grip strength decreases as risk of falls increases, and it should be considered that in physically active women aged over 50 years, the grip strength could be a predictor of falls and risk of fall.

Age and Sex-Related Decline of Muscle Strength Across the Adult Lifespan: A scoping review of aggregated data.

The results suggest that age-related isometric strength loss is similar between sexes while the characteristics of KE and KF peak torque decline are sex-related which likely explains the differential rate of age- related functional decline.

Effects of Dietary or Supplementary Micronutrients on Sex Hormones and IGF-1 in Middle and Older Age: A Systematic Review and Meta-Analysis

A systematic review of RCTs investigating effects of increasing dietary or supplemental micronutrient intake on sex hormones and IGF-1 in individuals aged 45 years or older found all trials had significant methodological limitations making effects of micronsutrient supplementation onsex hormones unclear.

Patient Screening



The Healthcare Costs of Sarcopenia in the United States

Objectives: To estimate the healthcare costs of sarcopenia in the United States and to examine the effect that a reduced sarcopenia prevalence would have on healthcare expenditures.

Novel treatment approaches to cachexia and sarcopenia: highlights from the 5th Cachexia Conference

Novel therapeutic approaches shown here include melanocortin-4 receptor antagonists, myostatin inhibition, β-blockers, IL-6 antagonism synthetic ghrelin and vitamin D.

Diet and Its Relationship with Grip Strength in Community‐Dwelling Older Men and Women: The Hertfordshire Cohort Study

OBJECTIVES: To examine relationships between diet and grip strength in older men and women and to determine whether prenatal growth modifies these relationships.

Does sarcopenia originate in early life? Findings from the Hertfordshire cohort study.

Birth weight is associated with sarcopenia in men and women, independently of adult height and weight, and the influence of infant growth on long-term muscle strength appears to be mediated through adult size.

Validated treatments and therapeutic perspectives regarding nutritherapy.

This chapter will focus on vitamin D as a compelling strategy with evidence for strength gain, fall and fracture prevention from double-blind randomized controlled trials.

Influence of resistance exercise on lean body mass in aging adults: a meta-analysis.

Findings suggest that RE participation earlier in life may provide superior effectiveness, and RE is effective for eliciting gains in LBM among aging adults, particularly with higher-volume programs.

Type 2 diabetes, muscle strength, and impaired physical function: the tip of the iceberg?

Whether there is a relationship among glucose tolerance, muscle strength, and physical function in men and women with and without type 2 diabetes is determined.

Age-associated changes in skeletal muscles and their effect on mobility: an operational diagnosis of sarcopenia.

Optimal cutoff values that can be used in the clinical practice to identify older persons with poor mobility were developed and lay the basis for a cost-effective, clinical marker of sarcopenia based on a measure of isometric handgrip strength.