Sarcopenia: The Role of poptosis and Modulation by Caloric Restriction

  title={Sarcopenia: The Role of poptosis and Modulation by Caloric Restriction},
  author={Amie J Dirks Naylor and C. Leeuwenburgh},
  journal={Exercise and Sport Sciences Reviews},
The mechanisms of sarcopenia have been slowly unraveled and likely involve activation of apoptosis. It is hypothesized that caloric restriction may, in part, attenuate sarcopenia by affecting apoptotic signaling. The signaling pathways responsible for the execution of apoptosis in aging muscle and the modulation of these pathways by caloric restriction are discussed. 
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