Sarcomeric Protein Mutations in Dilated Cardiomyopathy

  title={Sarcomeric Protein Mutations in Dilated Cardiomyopathy},
  author={Audrey N. Chang B.S. and James D. Potter},
  journal={Heart Failure Reviews},
This review aims to provide a concise summary of the DCM associated mutations identified in the proteins of the sarcomere and cytoskeleton, and discuss the reported effects of the mutations, as determined by functional studies, and in relation to the known structure of the protein affected. The mechanisms by which single missense mutations in the proteins… CONTINUE READING