Sarcomeric Pattern Formation by Actin Cluster Coalescence

  title={Sarcomeric Pattern Formation by Actin Cluster Coalescence},
  author={Benjamin M. Friedrich and Elisabeth Fischer-Friedrich and Nir S. Gov and Samuel A. Safran},
  booktitle={PLoS Computational Biology},
Contractile function of striated muscle cells depends crucially on the almost crystalline order of actin and myosin filaments in myofibrils, but the physical mechanisms that lead to myofibril assembly remains ill-defined. Passive diffusive sorting of actin filaments into sarcomeric order is kinetically impossible, suggesting a pivotal role of active processes in sarcomeric pattern formation. Using a one-dimensional computational model of an initially unstriated actin bundle, we show that actin… CONTINUE READING
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