Sarcomeric Pattern Formation by Actin Cluster Coalescence

@inproceedings{Friedrich2012SarcomericPF,
  title={Sarcomeric Pattern Formation by Actin Cluster Coalescence},
  author={Benjamin M. Friedrich and Elisabeth Fischer-Friedrich and Nir S. Gov and Samuel A. Safran},
  booktitle={PLoS Computational Biology},
  year={2012}
}
Contractile function of striated muscle cells depends crucially on the almost crystalline order of actin and myosin filaments in myofibrils, but the physical mechanisms that lead to myofibril assembly remains ill-defined. Passive diffusive sorting of actin filaments into sarcomeric order is kinetically impossible, suggesting a pivotal role of active processes in sarcomeric pattern formation. Using a one-dimensional computational model of an initially unstriated actin bundle, we show that actin… CONTINUE READING
Highly Cited
This paper has 26 citations. REVIEW CITATIONS
Related Discussions
This paper has been referenced on Twitter 2 times. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 13 extracted citations

Actin-Myosin Force Generation and Symmetry Breaking in the Model Contractile Fiber

SIAM Journal of Applied Mathematics • 2018
View 20 Excerpts
Highly Influenced

Nonlinear dynamics and fluctuations in biological systems

Kumulative Habilitationsschrift
2016
View 2 Excerpts

References

Publications referenced by this paper.
Showing 1-10 of 53 references

Active multistage coarsening of actin networks driven by myosin motors.

Proceedings of the National Academy of Sciences of the United States of America • 2011
View 2 Excerpts

A mechanical model of actin stress fiber formation and substrate elasticity sensing in adherent cells.

Proceedings of the National Academy of Sciences of the United States of America • 2010
View 1 Excerpt

Assembly and Dynamics of Myofibrils

Journal of biomedicine & biotechnology • 2010
View 2 Excerpts

Filament turnover stabilizes contractile cytoskeletal structures

P Guthardt Torres, K Doubrovinski, K Kruse
Eur Phys Lett • 2010
View 1 Excerpt

Similar Papers

Loading similar papers…