Sarcomatoid carcinoma of the prostate: progression from adenocarcinoma is associated with p53 over-expression.

@article{Delahunt1999SarcomatoidCO,
  title={Sarcomatoid carcinoma of the prostate: progression from adenocarcinoma is associated with p53 over-expression.},
  author={Brett Delahunt and John Nelson Eble and John N. Nacey and Stefan K. G. Grebe},
  journal={Anticancer research},
  year={1999},
  volume={19 5B},
  pages={4279-83}
}
BACKGROUND The pathogenesis of sarcomatoid metaplasia of prostatic adenocarcinoma is uncertain. The histologic features of sarcomatoid carcinoma arising in two patients with previously irradiated prostatic adenocarcinoma are reported and the relationship between prostatic adenocarcinoma and subsequent sarcomatoid carcinoma is investigated by immunohistochemical detection of epithelial and soft tissue tumor markers, and p53 protein. METHODS AND RESULTS Two patients, aged 72 and 67 years… CONTINUE READING

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