Sarcomas: genetics, signalling, and cellular origins. Part 2: TET-independent fusion proteins and receptor tyrosine kinase mutations.

@article{Suv2007SarcomasGS,
  title={Sarcomas: genetics, signalling, and cellular origins. Part 2: TET-independent fusion proteins and receptor tyrosine kinase mutations.},
  author={M-L Suv{\`a} and Luisa Cironi and Nicol{\`o} Riggi and Ivan Stamenkovic},
  journal={The Journal of pathology},
  year={2007},
  volume={213 2},
  pages={117-30}
}
Although the mechanisms that underlie sarcoma development are still poorly understood, the identification of non-random chromosomal translocations and receptor tyrosine kinase mutations associated with defined sarcoma types has provided new insight into the pathogenesis of these tumours. In Part 1 of the review (J Pathol 2007;213:4-20), we addressed sarcomas that express fusion genes containing TET gene family products. Part 2 of the review summarizes our current understanding of the… CONTINUE READING

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