Sarcoma growth factor (SGF): specific binding to epidermal growth factor (EGF) membrane receptors.

@article{Larco1980SarcomaGF,
  title={Sarcoma growth factor (SGF): specific binding to epidermal growth factor (EGF) membrane receptors.},
  author={Joseph E De Larco and George J. Todaro},
  journal={Journal of cellular physiology},
  year={1980},
  volume={102 2},
  pages={267-77}
}
Cells transformed by murine sarcoma viruses (MSV) produce and release into their tissue culture media several polypeptide growth stimulating factors. One of these has been partially purified using Bio-Gel P-60 column chromatography followed by DEAE-cellulose chromatography. This growth factor was assigned the name sarcoma growth factor (SGF), and is here shown to require the epidermal growth factor (EGF) receptor in order to function as a growth factor. DEAE-cellulose chromatography yielded a… CONTINUE READING
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