Sarcolemmal calcium transport in congestive heart failure due to myocardial infarction in rats.

@article{Dixon1992SarcolemmalCT,
  title={Sarcolemmal calcium transport in congestive heart failure due to myocardial infarction in rats.},
  author={Ian M. C. Dixon and Tomoji Hata and Naranjan S. Dhalla},
  journal={The American journal of physiology},
  year={1992},
  volume={262 5 Pt 2},
  pages={H1387-94}
}
Because Na(+)-Ca2+ exchange and Ca2+ pump are thought to play a role in sarcolemmal Ca2+ movements, we examined the Na(+)-dependent Ca(2+)-uptake and ATP-dependent Ca(2+)-uptake activities in failing heart after myocardial infarction in rats. The left coronary artery was ligated, and the viable left ventricle was used 4, 8, and 16 wk later; sham-operated animals served as controls. Increased left ventricular diastolic pressure and decreased positive and negative change in pressure over time… CONTINUE READING