Sarcolemmal K(ATP) channels: what do we really know?

  title={Sarcolemmal K(ATP) channels: what do we really know?},
  author={Thomas P. Flagg and Colin G. Nichols},
  journal={Journal of molecular and cellular cardiology},
  volume={39 1},
K(ATP) channels are present at an extremely high density in the heart, and we know from in vitro studies that channel activation causes dramatic action potential shortening and contractile failure. But, if and when this happens in vivo is still a matter of debate. Twenty one years of intense study have led to a well-developed understanding of the molecular… CONTINUE READING