Sarcolemmal (Ca2(+)+Mg2+)-ATPase of vascular smooth muscle and the effects of protein kinases thereupon.

@article{Imai1990SarcolemmalO,
  title={Sarcolemmal (Ca2(+)+Mg2+)-ATPase of vascular smooth muscle and the effects of protein kinases thereupon.},
  author={Shinichi Imai and Yuzo Yoshida and Hai Tao Sun},
  journal={Journal of biochemistry},
  year={1990},
  volume={107 5},
  pages={755-61}
}
To elucidate the regulation mechanisms for sarcolemmal Ca2(+)-pumping ATPase of vascular smooth muscle, the preparation of the membrane fraction of porcine aorta with which the enzyme activity could be analyzed was attempted. A Ca2(+)-activated, Mg2(+)-dependent ATPase [Ca2(+)+Mg2+)-ATPase) activity with high affinity for Ca2+ (Km = 79 +/- 18 nM) was found in a sarcolemma-enriched fraction obtained from digitonin-treated microsomes that possessed the essential properties of plasma membrane (PM… CONTINUE READING

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