Sarcoidosis-associated fatigue: an often forgotten symptom

@article{Kapoor2013SarcoidosisassociatedFA,
  title={Sarcoidosis-associated fatigue: an often forgotten symptom},
  author={Shailendra Kapoor},
  journal={Expert Review of Clinical Immunology},
  year={2013},
  volume={9},
  pages={109 - 110}
}
  • S. Kapoor
  • Published 2013
  • Medicine
  • Expert Review of Clinical Immunology
I read with great interest the recent article by Baughman and Nunes [1]. An aspect of sarcoidosis that is often forgotten is disease-associated fatigue and lassitude. Younger individuals afflicted with sarcoidosis report more fatigue than older patients [2]. Moreover, fatigue is more common in females than in males. Nearly 47% of male patients with sarcoidisis have decreased testosterone levels [3]. This further contributes to sarcoidosis-associated fatigue. Similarly, sarcoidoisis may result… Expand
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References

SHOWING 1-9 OF 9 REFERENCES
Fatigue in patients with sarcoidosis, compared with the general population.
TLDR
Compared with the general population, young sarcoidosis patients are especially affected by fatigue, and the comparison to norm data is highly recommended for the evaluation of age and gender differences. Expand
Fatigue is associated with quality of life in sarcoidosis patients.
TLDR
If these results were to be replicated in a prospective study, fatigue as measured by the FAS could be a good indicator of QOL in sarcoidosis patients. Expand
Armodafinil for sarcoidosis-associated fatigue: a double-blind, placebo-controlled, crossover trial.
TLDR
Armodafinil treatment led to a significant reduction in fatigue in sarcoidosis patients, seen even in patients who did not have excessive daytime somnolence. Expand
Hypogonadism in male outpatients with sarcoidosis.
TLDR
Non-significant relationships were found between sex hormones, clinical outcomes and C-reactive protein in patients with sarcoidosis, and poor inspiratory and quadriceps muscle function, exercise intolerance, diminished vitality and depressed mood were not related to hypogonadism in these patients. Expand
Reduced Th2 cytokine production by sarcoidosis patients in clinical remission with chronic fatigue
TLDR
In chronically fatigued sarcoidosis patients in clinical remission, a cytokine/chemokine profile is found which is suggestive for a less competent Th2 counterbalancing capacity, that may contribute to the persistence of chronic fatigue. Expand
An elderly patient with sarcoidosis manifesting panhypopituitarism with central diabetes insipidus.
TLDR
Diffuse damage of anterior pituitary combined with hypothalamic involvement leading to central diabetes insipidus is a rare manifestation in such elderly patients with neurosarcoidosis. Expand
Double-blind, randomized trial of dexmethylphenidate hydrochloride for the treatment of sarcoidosis-associated fatigue.
TLDR
Treatment with d-MPH was associated with a significant improvement in sarcoidosis-associated fatigue and was well tolerated. Expand
Therapy for sarcoidosis: evidence-based recommendations
TLDR
A stepwise approach to treatment of sarcoidosis is outlined, based on available evidence, which shows that other agents have been shown to be steroid sparing, and therefore useful for long-term management. Expand
Armodafinil for sarcoidosisassociated fatigue: a double-blind, placebo-controlled