author={O. Dempsey and E. Paterson and K. Kerr and A. Denison},
  journal={BMJ : British Medical Journal},
Around 3000 new cases of sarcoidosis are diagnosed each year in the United Kingdom. General practitioners play a key role in the early recognition of the most common clinical presentations of this multifaceted disease, and they usually direct initial assessment and specialist referral. Although prognosis is excellent for most patients, a minority will develop life threatening complications and may need potentially toxic treatments. Most patients are young and understandably alarmed at having… Expand
1 Citations
Tattoo skin reaction as a skin manifestation of systemic sarcoidosis
This case illustrates that skin changes on tattoos can be a presenting manifestation of systemic sarcoidosis and that skin biopsy is useful in early diagnosis. Expand


Clinical characteristics of patients in a case control study of sarcoidosis.
It is concluded that the initial presentation of sarcoidosis is related to sex, race, and age. Expand
Epidemiology of familial sarcoidosis in the UK.
Results support the theory that a shared determinant (either genetic or environmental) is operating in familial sarcoidosis and suggest that this determinant is similar for all ethnic groups. Expand
Corticosteroids for pulmonary sarcoidosis.
Oral steroids improved the chest X-ray and a global score of CXR, symptoms and spirometry over 6-24 months, but there is little evidence of an improvement in lung function. Expand
Inhibitors of tumor necrosis factor (TNF) in sarcoidosis: who, what, and how to use them.
A stepwise approach is proposed to increase the likelihood of disease improvement for patients who experience an inadequate response to an anti-TNF agent as well as the relative benefits and side effects of the three anti- TNF biological agents for treating sarcoidosis. Expand
Familial aggregation of sarcoidosis. A case-control etiologic study of sarcoidosis (ACCESS).
A significant elevated risk of sarcoidosis was observed among first- and second-degree relatives of sarCOidosis cases compared with relatives of matched control subjects. Expand
Molecular evidence for the role of mycobacteria in sarcoidosis: a meta-analysis
The results of the current study illustrate a demonstrable mycobacterial presence in sarcoidosis lesions suggesting an association between my cobacteria and some cases of sarCOidosis. Expand
Racial differences in sarcoidosis incidence: a 5-year study in a health maintenance organization.
The results should be more generalizable than previous studies done with select populations and should serve as a useful frame of reference for future epidemiologic research of sarcoidosis. Expand
Association of fatigue with an acute phase response in sarcoidosis.
The presence of an acute phase response as indicated by metabolic derangements and a moderate increase in C-reactive protein levels in sarcoidosis is confirmed, particularly in those patients with constitutional symptoms. Expand
Heredity in sarcoidosis: a registry-based twin study
Twin concordance and heritability estimates suggest that genetic factors play an important role in the susceptibility to sarcoidosis and should encourage the search for molecular genetic markers of susceptibility to the disease. Expand
Immunosuppressive and cytotoxic therapy for pulmonary sarcoidosis.
The current body of evidence supporting the use of immunosuppressive agents and cytotoxic therapies is limited and side-effects associated with some of the therapies were severe. Expand