Sarcoidosis—scientific progress and clinical challenges

@article{Chen2011SarcoidosisscientificPA,
  title={Sarcoidosis—scientific progress and clinical challenges},
  author={E. Chen and D. Moller},
  journal={Nature Reviews Rheumatology},
  year={2011},
  volume={7},
  pages={457-467}
}
Sarcoidosis is an uncommon systemic inflammatory disorder characterized by noncaseating granulomatous inflammation that most commonly affects the lungs, intrathoracic lymph nodes, eyes and skin. One-third or more of patients with sarcoidosis have chronic, unremitting inflammation with progressive organ impairment. Findings of family and genetic studies indicate a genetic susceptibility to sarcoidosis, with genes in the MHC region having a dominant role. Immunologic hallmarks of the disease… Expand
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