SarT, a repressor of alpha-hemolysin in Staphylococcus aureus.

  title={SarT, a repressor of alpha-hemolysin in Staphylococcus aureus.},
  author={Katherine A. Schmidt and Adhar C. Manna and Sabrina Gill and Ambrose L. Cheung},
  journal={Infection and immunity},
  volume={69 8},
In searching the Staphylococcus aureus genome, we found several homologs to SarA. One of these genes, sarT, codes for a basic protein with 118 residues and a predicted molecular size of 16,096 Da. Northern blot analysis revealed that the expression of sarT was repressed by sarA and agr. An insertion sarT mutant generated in S. aureus RN6390 and 8325-4 backgrounds revealed minimal effect on the expression of sarR and sarA. The RNAIII level was notably increased in the sarT mutant, particularly… CONTINUE READING

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