SarA and not sigmaB is essential for biofilm development by Staphylococcus aureus.

@article{Valle2003SarAAN,
  title={SarA and not sigmaB is essential for biofilm development by Staphylococcus aureus.},
  author={Jaione Valle and Alejandro Toledo-Arana and Carmen Berasain and Jean-Marc Ghigo and B. Zandio Amorena and Jos{\'e} R Penad{\'e}s and I{\~n}igo Lasa},
  journal={Molecular microbiology},
  year={2003},
  volume={48 4},
  pages={
          1075-87
        }
}
Staphylococcus aureus biofilm formation is associated with the production of the polysaccharide intercellular adhesin (PIA/PNAG), the product of the ica operon. The staphylococcal accessory regulator, SarA, is a central regulatory element that controls the production of S. aureus virulence factors. By screening a library of Tn917 insertions in a clinical S. aureus strain, we identified SarA as being essential for biofilm development. Non-polar mutations of sarA in four genetically unrelated S… CONTINUE READING

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