Sar1p N-Terminal Helix Initiates Membrane Curvature and Completes the Fission of a COPII Vesicle

@article{Lee2005Sar1pNH,
  title={Sar1p N-Terminal Helix Initiates Membrane Curvature and Completes the Fission of a COPII Vesicle},
  author={Marcus C. S. Lee and Lelio Orci and Susan T. Hamamoto and Eugene Futai and Mariella Ravazzola and Randy Schekman},
  journal={Cell},
  year={2005},
  volume={122},
  pages={605-617}
}
Secretory proteins traffic from the ER to the Golgi via COPII-coated transport vesicles. The five core COPII proteins (Sar1p, Sec23/24p, and Sec13/31p) act in concert to capture cargo proteins and sculpt the ER membrane into vesicles of defined geometry. The molecular details of how the coat proteins deform the lipid bilayer into vesicles are not known. Here we show that the small GTPase Sar1p directly initiates membrane curvature during vesicle biogenesis. Upon GTP binding by Sar1p, membrane… CONTINUE READING
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Dynamics of the COPII coat with GTP and stable analogues

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