Saposins utilize two strategies for lipid transfer and CD1 antigen presentation.

  title={Saposins utilize two strategies for lipid transfer and CD1 antigen presentation.},
  author={Luis {\'A}ngel Le{\'o}n and Raju V. V. Tatituri and Rosa Grenha and Ying Sun and Duarte C Barral and Adriaan J Minnaard and Veemal Bhowruth and Natacha Veerapen and Gurdyal S Besra and Anne G. Kasmar and Wei Peng and D. Branch Moody and Gregory A. Grabowski and Michael B Brenner},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={109 12},
Transferring lipid antigens from membranes into CD1 antigen-presenting proteins represents a major molecular hurdle necessary for T-cell recognition. Saposins facilitate this process, but the mechanisms used are not well understood. We found that saposin B forms soluble saposin protein-lipid complexes detected by native gel electrophoresis that can directly load CD1 proteins. Because saposin B must bind lipids directly to function, we found it could not accommodate long acyl chain containing… CONTINUE READING

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T Cell Activation by CD1 and Lipid Antigens (Springer, New York)

  • DB Moody
  • 2007

Total synthesis of enantiopure beta - D - mannosyl phosphomycoketides from Mycobacterium tuberculo

  • DB Moody
  • J Am Chem Soc
  • 2006

Total synthesis of enantiopure beta-D-mannosyl phosphomycoketides from Mycobacterium tuberculosis

  • RP van Summeren, DB Moody, BL Feringa, AJ Minnaard
  • J Am Chem Soc 128:4546–4547
  • 2006

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