Saporin and ricin A chain follow different intracellular routes to enter the cytosol of intoxicated cells.

@article{Vago2005SaporinAR,
  title={Saporin and ricin A chain follow different intracellular routes to enter the cytosol of intoxicated cells.},
  author={Riccardo Vago and Catherine J. Marsden and J. Michael Lord and Rodolfo Ippoliti and David J. Flavell and Sopsamorn-U Flavell and Aldo Ceriotti and Maria Serena Fabbrini},
  journal={The FEBS journal},
  year={2005},
  volume={272 19},
  pages={4983-95}
}
Several protein toxins, such as the potent plant toxin ricin, enter mammalian cells by endocytosis and undergo retrograde transport via the Golgi complex to reach the endoplasmic reticulum (ER). In this compartment the catalytic moieties exploit the ER-associated degradation (ERAD) pathway to reach their cytosolic targets. Bacterial toxins such as cholera toxin or Pseudomonas exotoxin A carry KDEL or KDEL-like C-terminal tetrapeptides for efficient delivery to the ER. Chimeric toxins containing… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 29 extracted citations

Similar Papers

Loading similar papers…