Saponins modulate the intracellular trafficking of protein toxins.

  title={Saponins modulate the intracellular trafficking of protein toxins.},
  author={Alexander Weng and Mayank Thakur and Benedicta von Mallinckrodt and Figen Beceren-Braun and Roger Gilabert-Oriol and Burkard Wiesner and Jenny Eichhorst and Stefan Boettger and Matthias Friedrich Melzig and Hendrik Fuchs},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  volume={164 1},
Type I ribosome inactivating proteins such as saporin from the plant Saponaria officinalis L. are widely used as toxin moieties of targeted anti-tumor toxins. For exerting cytotoxicity the toxin moieties have to be released into the cytosol of tumor cells. However the cytosolic transfer of toxin molecules into the cytosol is mostly an inefficient process. In this report we demonstrate that certain saponins, which are also biosynthesized by Saponaria officinalis L., specifically mediate the… CONTINUE READING
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