Saponins in tumor therapy.

  title={Saponins in tumor therapy.},
  author={Christopher Bachran and Silke Bachran and Mark V. Sutherland and Diana Bachran and Hendrik Fuchs},
  journal={Mini reviews in medicinal chemistry},
  volume={8 6},
Saponins are plant glycosides with favorable anti-tumorigenic properties. Several saponins inhibit tumor cell growth by cell cycle arrest and apoptosis with IC50 values of up to 0.2 microM. We discuss diverse groups of saponins (dioscins, saikosaponins, julibrosides, soy saponins, ginseng saponins and avicins) investigated in relation to tumor therapy and focus on cellular and systemic mechanisms of tumor cell growth inhibition both in vitro and in vivo. The review also describes saponins in… CONTINUE READING

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