Saponins from Panax japonicus attenuate D-galactose-induced cognitive impairment through its anti-oxidative and anti-apoptotic effects in rats.

@article{Wang2015SaponinsFP,
  title={Saponins from Panax japonicus attenuate D-galactose-induced cognitive impairment through its anti-oxidative and anti-apoptotic effects in rats.},
  author={Ting Wang and Guojie Di and Li Yang and Yaoyan Dun and Zhiwei Sun and Jingzhi Wan and Ben Peng and Chaoqi Liu and Guangrun Xiong and Changcheng Zhang and Ding Yuan},
  journal={The Journal of pharmacy and pharmacology},
  year={2015},
  volume={67 9},
  pages={
          1284-96
        }
}
OBJECTIVE To investigate the neuroprotective effects of saponins from Panax japonicus (SPJ) on D-galactose (D-gal)-induced brain ageing, and further explore the underlying mechanisms. METHODS SPJ were analysed using high-pressure liquid chromatography. Male Wistar rats weighing 200 ± 20 g were randomly divided into four groups: control group (saline), D-gal-treated group (400 mg/kg, subcutaneously), D-gal + SPJ groups (50, 100 and 200 mg/kg, orally) and vitamin E group (100 mg/kg). Rats were… CONTINUE READING

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