Sanpodo controls sensory organ precursor fate by directing Notch trafficking and binding γ-secretase

@inproceedings{Upadhyay2013SanpodoCS,
  title={Sanpodo controls sensory organ precursor fate by directing Notch trafficking and binding γ-secretase},
  author={Alok Upadhyay and Vasundhara Kandachar and Diana Zitserman and Xin Tong and Fabrice Roegiers},
  booktitle={The Journal of cell biology},
  year={2013}
}
In Drosophila peripheral neurogenesis, Notch controls cell fates in sensory organ precursor (SOP) cells. SOPs undergo asymmetric cell division by segregating Numb, which inhibits Notch signaling, into the pIIb daughter cell after cytokinesis. In contrast, in the pIIa daughter cell, Notch is activated and requires Sanpodo, but its mechanism of action has not been elucidated. As Sanpodo is present in both pIIa and pIIb cells, a second role for Sanpodo in regulating Notch signaling in the low… CONTINUE READING
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