Sannanine, a new cytotoxic alkaloid from Streptomyces sannanensis

  title={Sannanine, a new cytotoxic alkaloid from Streptomyces sannanensis},
  author={Yiqing Li and Dan Zheng and Jun Li and Li Han and Xiaolong Cui and Li Lang and Ming-gang Li and Zhanyou Wang and Jiang-yuan Zhao and Xueshi Huang},
  journal={The Journal of Antibiotics},

Untargeted Metabolomics of Streptomyces Species Isolated from Soils of Nepal

The characterization of actinomycetes from Nepal based on their morphology, 16S rRNA gene sequencing, and metabolic profiling are showcased, revealing that the isolates BN6 and BN14 are closely related to Streptomyces species.

Investigation of anti‐inflammatory and toxicity effects of mangrove‐derived Streptomyces rochei strain VITGAP173

Inhibition of nitric oxide and cyclooxygenase enzymes upon lipopolysaccharide‐induced inflammation were utilized to evaluate the anti‐inflammatory efficacy, and the results showed the potency of VITGAP173 in a dose‐dependent manner.

Total synthesis of sannanine and analogues thereof

The first total synthesis of Sannanine has been accomplished with an overall 30% yield in a concise manner. The key strategies involve Friedländer quinoline synthesis, demethylation, in situ

Biologically active quinoline and quinazoline alkaloids part I

Over 200 molecules with a broad range of bioactivities, including antitumor, antimalarial, antibacterial and antifungal, antiparasitic and insecticidal, antiviral, antiplatelet, anti‐inflammatory, herbicidal, antioxidant and other activities, were reviewed.

Biologically active quinoline and quinazoline alkaloids part II

This survey should provide new clues or possibilities for the discovery of new and better drugs from the original naturally occurring quinoline and quinazoline alkaloids.

Quinoline and naphthalene derivatives from Saccharopolyspora sp. YIM M13568

Quinoline, a well-known heterocyclic compound, itself has few applications; however, many of its derivatives are useful in diverse therapeutic applications,1,2 such as antimalarials (Quinine and

Diversity, Antimicrobial Activity, and Biosynthetic Potential of Cultivable Actinomycetes Associated with Lichen Symbiosis

The results demonstrate that the lichens of Yunnan Province represent an extremely rich reservoir for the isolation of a significant diversity of actinomycetes, including novel species, which are potential source for discovering biologically active compounds.

Isostreptazolin and Sannaphenol, Two New Metabolites from Streptomyces sannanensis

Two new compounds, isostreptazolin (1) and sannaphenol (2), were isolated from the culture broth of Streptomyces sannanensis and their structures elucidated on the basis of 1D and 2D NMR as well as



Chemistry of Quinoline-5,8-diones

The replacement of an amino group on a quinone ring by alkoxy groups to produce 9−11 is reported for the first time and offers easy routes for the syntheses of these alkoxy derivatives.

Regioselective 6-Amination and 6-Arylation of 5,8-Quinolinedione Promoted by Metal Ions

The effects of some metal ions on the amination and arylation of 5,8-quinolinedione (1) and on the amine displacement of 6-piperidino-5,8-quinolinedione have been investigated. The reaction of 1 with

Preparation of 7-alkylamino-2-methylquinoline-5,8-diones.

This work has achieved an unusual hydrobromic acid catalyzed debromination reactions of several 6-bromo-7-alkylamino-2-methylquinoline-5,8-diones, giving 7-alkyamino- 2-methyl benzene-5-8-Diones in good yields.

Discovery and biological evaluation of a new family of potent inhibitors of the dual specificity protein phosphatase Cdc25.

Using a chemical complementation assay, it was found that NSC 663284 blocked cellular Erk dephosphorylation caused by ectopic Cdc25A expression, and computational electrostatic potential mapping suggested the need for an electron-deficient 7-position for maximal inhibitor activity.

7-Chloro-6-piperidin-1-yl-quinoline-5,8-dione (PT-262), a novel synthetic compound induces lung carcinoma cell death associated with inhibiting ERK and CDC2 phosphorylation via a p53-independent pathway

PT-262 suppresses the phosphorylation of ERK and CDC2 associated with proliferation inhibition via a p53-independent pathway in human lung cancer cells and induces cytotoxicity via a concentration-dependent manner.

Comparative study on biological activities of heterocyclic quinones and streptonigrin.

The membrane transport of the quinones was evaluated by comparing the effects on oxygen consumption by mitochondria and oxidation of NADH by bacterial diaphorase, being proven not to be responsible for their lower cytotoxicities.

Evaluation of a tetrazolium-based semiautomated colorimetric assay: assessment of radiosensitivity.

While optimal conditions for each cell line (cell number plated and doubling time) must be established, the 3-dimethylthiazol-2-yl)-2,5-diphenylformazan bromide assay could be automated and thus be of great value in screening large numbers of potential radiosensitizers or protectors.