Sanguisorba Officinalis Root Extract Has FGF-5 Inhibitory Activity and Reduces Hair Loss by Causing Prolongation of the Anagen Period

@inproceedings{Maeda2011SanguisorbaOR,
  title={Sanguisorba Officinalis Root Extract Has FGF-5 Inhibitory Activity and Reduces Hair Loss by Causing Prolongation of the Anagen Period},
  author={Tetsuo Maeda and Takuya Yamamoto and Y Isikawa},
  year={2011}
}
FGF-5 inhibitors with FGF-5-antagonizing activity may be effective against hair loss, as these inhibitors suppress the transition of hair follicles from the anagen to catagen phase caused by FGF-5. We screened 24 substances for their FGF-5-antagonizing activity using both an FGF receptor-1c-transfected Ba/F3 cell line and the C3H mouse, and finally detected Sanguisorba Officinalis Root Extract (SO extract) as a reliable FGF-5 inhibitor. Topical application of SO extract elongated the anagen… 
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Promotion of anagen, increased hair density and reduction of hair fall in a clinical setting following identification of FGF5-inhibiting compounds via a novel 2-stage process

Isolates from the monoterpenoid family displayed efficacy in FGF5 inhibition in vitro, and a topical formulation containing a leading isolate significantly improved AT ratio, reduced hair fall and increased apparent hair density in the tested population of men and women.