Sanguinarine interacts with chromatin, modulates epigenetic modifications, and transcription in the context of chromatin.

@article{RuthrothaSelvi2009SanguinarineIW,
  title={Sanguinarine interacts with chromatin, modulates epigenetic modifications, and transcription in the context of chromatin.},
  author={B RuthrothaSelvi and Suman Kalyan Pradhan and Jayasha Shandilya and Chandrima Das and Badi Sri Sailaja and G NagaShankar and Shrikanth S. Gadad and Ashok Reddy and Dipak Dasgupta and Tapas Kumar Kundu},
  journal={Chemistry & biology},
  year={2009},
  volume={16 2},
  pages={203-16}
}
DNA-binding anticancer agents cause alteration in chromatin structure and dynamics. We report the dynamic interaction of the DNA intercalator and potential anticancer plant alkaloid, sanguinarine (SGR), with chromatin. Association of SGR with different levels of chromatin structure was enthalpy driven with micromolar dissociation constant. Apart from DNA, it binds with comparable affinity with core histones and induces chromatin aggregation. The dual binding property of SGR leads to inhibition… CONTINUE READING

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