Sanguinarine induces K+ outflow from yeast cells expressing mammalian sodium pumps

@article{ScheinerBobis2000SanguinarineIK,
  title={Sanguinarine induces K+ outflow from yeast cells expressing mammalian sodium pumps},
  author={Georgios Scheiner-Bobis},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={2000},
  volume={363},
  pages={203-208}
}
Abstract. Sanguinarine, an alkaloid from Sanguinaria canadensis, has no effect on the yeast Saccharomyces cerevisiae at concentrations of up to 225 µM. Yeast cells become sensitive to sanguinarine and lose cytosolic K+ in a time- and concentration-dependent manner when they express the mammalian Na+,K+-ATPase (sodium pump). Dose-response studies show that sanguinarine induces K+ outflow from cells expressing wild-type sodium pumps with an EC50 of 29.3±1.2 µM. A similar effect with a comparable… CONTINUE READING

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