• DOI:10.1517/17425255.2013.773973
Corpus ID: 27593521

Sandwich-cultured hepatocytes: utility for in vitro exploration of hepatobiliary drug disposition and drug-induced hepatotoxicity

@article{Bruyn2013SandwichculturedHU,
  title={Sandwich-cultured hepatocytes: utility for in vitro exploration of hepatobiliary drug disposition and drug-induced hepatotoxicity},
  author={T. de Bruyn and Sagnik Chatterjee and S. Fattah and Janneke Keemink and J. Nicola{\"i} and P. Augustijns and P. Annaert},
  journal={Expert Opinion on Drug Metabolism & Toxicology},
  year={2013},
  volume={9},
  pages={589 - 616}
}

T. de Bruyn, Sagnik Chatterjee, +4 authors P. Annaert

Published 2013

Medicine

Expert Opinion on Drug Metabolism & Toxicology

Introduction: The sandwich-cultured hepatocyte (SCH) model has become an invaluable in vitro tool for studying hepatic drug transport, metabolism, biliary excretion and toxicity. The relevant expression of many hepatocyte-specific functions together with the in vivo-like morphology favor SCHs over other preclinical models for evaluating hepatobiliary drug disposition and drug-induced hepatotoxicity. Areas covered: In this review, the authors highlight recommended procedures required for… CONTINUE READING

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