Sandwich-cultured hepatocytes: utility for in vitro exploration of hepatobiliary drug disposition and drug-induced hepatotoxicity

  title={Sandwich-cultured hepatocytes: utility for in vitro exploration of hepatobiliary drug disposition and drug-induced hepatotoxicity},
  author={T. de Bruyn and Sagnik Chatterjee and S. Fattah and Janneke Keemink and J. Nicola{\"i} and P. Augustijns and P. Annaert},
  journal={Expert Opinion on Drug Metabolism & Toxicology},
  pages={589 - 616}
  • T. de Bruyn, Sagnik Chatterjee, +4 authors P. Annaert
  • Published 2013
  • Medicine
  • Expert Opinion on Drug Metabolism & Toxicology
  • Introduction: The sandwich-cultured hepatocyte (SCH) model has become an invaluable in vitro tool for studying hepatic drug transport, metabolism, biliary excretion and toxicity. The relevant expression of many hepatocyte-specific functions together with the in vivo-like morphology favor SCHs over other preclinical models for evaluating hepatobiliary drug disposition and drug-induced hepatotoxicity. Areas covered: In this review, the authors highlight recommended procedures required for… CONTINUE READING
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