Sampling the Antibiotic Resistome

@article{DCosta2006SamplingTA,
  title={Sampling the Antibiotic Resistome},
  author={Vanessa M D'Costa and Katherine M McGrann and Donald W. Hughes and Gerard D. Wright},
  journal={Science},
  year={2006},
  volume={311},
  pages={374 - 377}
}
Microbial resistance to antibiotics currently spans all known classes of natural and synthetic compounds. It has not only hindered our treatment of infections but also dramatically reshaped drug discovery, yet its origins have not been systematically studied. Soil-dwelling bacteria produce and encounter a myriad of antibiotics, evolving corresponding sensing and evading strategies. They are a reservoir of resistance determinants that can be mobilized into the microbial community. Study of this… 
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The analysis of transposon-tagged Pseudomonas aeruginosa mutants presented in this article shows that this phenotype emerges from the action of numerous proteins from all functional categories, defining novel mechanisms for mutation-driven acquisition of antibiotic resistance.
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