Sampling rare events: statistics of local sequence alignments.

  title={Sampling rare events: statistics of local sequence alignments.},
  author={Alexander K. Hartmann},
  journal={Physical review. E, Statistical, nonlinear, and soft matter physics},
  volume={65 5 Pt 2},
  • A. Hartmann
  • Published 13 August 2001
  • Computer Science
  • Physical review. E, Statistical, nonlinear, and soft matter physics
A method to calculate probability distributions in regions where the events are very unlikely (e.g., p approximately 10(-40)) is presented. The basic idea is to map the underlying model on a physical system. The system is simulated at a low temperature, such that preferably configurations with originally low probabilities are generated. Since the distribution of such a physical system is known, the original unbiased distribution can be obtained. As an application, local alignment of protein… 

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