Sampling phasic dopamine signaling with fast-scan cyclic voltammetry in awake, behaving rats.

Abstract

Fast-scan cyclic voltammetry (FSCV) is an electrochemical technique that permits the in vivo measurement of extracellular fluctuations in multiple chemical species. The technique is frequently utilized to sample sub-second (phasic) concentration changes of the neurotransmitter dopamine in awake and behaving rats. Phasic dopamine signaling is implicated in reinforcement, goal-directed behavior, and locomotion, and FSCV has been used to investigate how rapid changes in striatal dopamine concentration contribute to these and other behaviors. This unit describes the instrumentation and construction, implantation, and use of components required to sample and analyze dopamine concentration changes in awake rats with FSCV.

DOI: 10.1002/0471142301.ns0725s70
01020201520162017
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Cite this paper

@article{Fortin2015SamplingPD, title={Sampling phasic dopamine signaling with fast-scan cyclic voltammetry in awake, behaving rats.}, author={Samantha M. Fortin and Jackson J. Cone and Scott Ng-Evans and James Edgar McCutcheon and Mitchell F. Roitman}, journal={Current protocols in neuroscience}, year={2015}, volume={70}, pages={7.25.1-20} }