Sampling error and intraobserver variation in liver biopsy in patients with chronic HCV infection

  title={Sampling error and intraobserver variation in liver biopsy in patients with chronic HCV infection},
  author={Arie Regev and Mariana E. Berho and Lennox J. Jeffers and Clara Milikowski and Enrique G. Molina and Nikolaos T. Pyrsopoulos and Zheng Feng and K. Rajender Reddy and Eugene R Schiff},
  journal={American Journal of Gastroenterology},
OBJECTIVES:Needle liver biopsy has been shown to have a high rate of sampling error in patients with diffuse parenchymal liver diseases. In these cases, the sample of liver tissue does not reflect the true degree of inflammation, fibrosis, or cirrhosis, despite an adequate sample size. The aim of this study was to determine the rate and extent of sampling error in patients with chronic hepatitis C virus infection, and to assess the intraobserver variation with the commonly used scoring system… 

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