Sampling distribution for microsatellites amplified by PCR: mean field approximation and its applications to genotyping.

@article{Lai2004SamplingDF,
  title={Sampling distribution for microsatellites amplified by PCR: mean field approximation and its applications to genotyping.},
  author={Yinglei Lai and Fengzhu Sun},
  journal={Journal of theoretical biology},
  year={2004},
  volume={228 2},
  pages={185-94}
}
Due to microsatellite mutations during PCR, stutter patterns may appear in the final PCR product, which hinder us from accurate genotyping microsatellite markers. The existing methods for microsatellite stutter pattern deconvolution required large amount of data. A mathematical model for microsatellite mutations during PCR and an estimation method based on… CONTINUE READING