Sample size for two-stage studies with maintenance therapy.

  title={Sample size for two-stage studies with maintenance therapy.},
  author={Wentao Feng and Abdus S Wahed},
  journal={Statistics in medicine},
  volume={28 15},
An adaptive treatment strategy (ATS) is defined as a sequence of treatments and intermediate responses. ATS' arise when chronic diseases such as cancer and depression are treated over time with various treatment alternatives depending on intermediate responses to earlier treatments. Clinical trials are often designed to compare ATSs based on appropriate designs such as sequential randomization designs. Although recent literature provides statistical methods for analyzing data from such trials… CONTINUE READING