Sample size for detecting differentially expressed genes in microarray experiments

@article{Wang2004SampleSF,
  title={Sample size for detecting differentially expressed genes in microarray experiments},
  author={Sue-Jane Wang and James J. Chen},
  journal={BMC Genomics},
  year={2004},
  volume={5},
  pages={87 - 87}
}
Microarray experiments are often performed with a small number of biological replicates, resulting in low statistical power for detecting differentially expressed genes and concomitant high false positive rates. While increasing sample size can increase statistical power and decrease error rates, with too many samples, valuable resources are not used efficiently. The issue of how many replicates are required in a typical experimental system needs to be addressed. Of particular interest is the… CONTINUE READING