Sample size calculations for a split-cluster, beta-binomial design in the assessment of toxicity.

Abstract

Mouse embryo assays are recommended to test materials used for in vitro fertilization for toxicity. In such assays, a number of embryos is divided in a control group, which is exposed to a neutral medium, and a test group, which is exposed to a potentially toxic medium. Inferences on toxicity are based on observed differences in successful embryo… (More)

Topics

Cite this paper

@article{Hendriks2005SampleSC, title={Sample size calculations for a split-cluster, beta-binomial design in the assessment of toxicity.}, author={J. C. M. Hendriks and Steven Teerenstra and J P E M Punt-van der Zalm and Alex M. M. Wetzels and James R. Westphal and G. F. Borm}, journal={Statistics in medicine}, year={2005}, volume={24 24}, pages={3757-72} }