Sample size calculation for comparing two negative binomial rates.

  title={Sample size calculation for comparing two negative binomial rates.},
  author={Haiyuan Zhu and Hassan D Lakkis},
  journal={Statistics in medicine},
  volume={33 3},
Negative binomial model has been increasingly used to model the count data in recent clinical trials. It is frequently chosen over Poisson model in cases of overdispersed count data that are commonly seen in clinical trials. One of the challenges of applying negative binomial model in clinical trial design is the sample size estimation. In practice, simulation methods have been frequently used for sample size estimation. In this paper, an explicit formula is developed to calculate sample size… CONTINUE READING
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