Sample size and power for prospective analysis of relative risk.

@article{Blackwelder1993SampleSA,
  title={Sample size and power for prospective analysis of relative risk.},
  author={William C Blackwelder},
  journal={Statistics in medicine},
  year={1993},
  volume={12 7},
  pages={691-8}
}
In a placebo-controlled vaccine efficacy trial or a trial of equivalence of vaccines, one may wish to show that relative risk of disease is less than a specified value R0, not equal to one. This paper compares three methods for estimating relative risk in the binomial setting, based on a logarithmic transformation, likelihood scores, and a Poisson approximation. Exact power and size of test are calculated by enumeration of possible binomial outcomes, and power is approximated from asymptotic… CONTINUE READING

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