Sample size and power calculations in repeated measurement analysis

  title={Sample size and power calculations in repeated measurement analysis},
  author={Chul Ahn and John E. Overall and Scott Tonidandel},
  journal={Computer methods and programs in biomedicine},
  volume={64 2},
Controlled clinical trials in neuropsychopharmacology, as in numerous other clinical research domains, tend to employ a conventional parallel-groups design with repeated measurements. The hypothesis of primary interest in the relatively short-term, double-blind trials, concerns the difference between patterns or magnitudes of change from baseline. A simple two-stage approach to the analysis of such data involves calculation of an index or coefficient of change in stage 1 and testing the… CONTINUE READING


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