Sample preparation for liquid chromatography-tandem mass spectrometry using functionalized ferromagnetic micro-particles.

Abstract

OBJECTIVES To study the applicability of functionalized ferromagnetic micro-particles in the sample preparation for quantification of small molecules by LC-MS/MS. DESIGN AND METHODS A representative analyte (itraconazole) was extracted from plasma samples using small quantities of C18-modified ferromagnetic micro-particles. RESULTS 125 microg of… (More)
DOI: 10.1016/j.clinbiochem.2008.08.001

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