Sample preparation development and matrix effects evaluation for multianalyte determination in urine.

@article{Marchi2009SamplePD,
  title={Sample preparation development and matrix effects evaluation for multianalyte determination in urine.},
  author={Ivano Marchi and Serge Laurent Rudaz and J. -L. Veuthey},
  journal={Journal of pharmaceutical and biomedical analysis},
  year={2009},
  volume={49 2},
  pages={
          459-67
        }
}
The development of a generic analytical method remains difficult when a high number of compounds has to be simultaneously considered. This study proposes an innovative strategy for the development of a solid phase extraction (SPE) procedure before liquid chromatography-mass spectrometry analysis of 34 diuretics and beta-blockers in urine samples. These compounds have been selected since they are often encountered in anti-doping control. The principle is based on the selection of representative… CONTINUE READING
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